(ぼつらく) To be ruined, bankrupt, downfallen. But usually ruined, or washed-up.   NP
(めつぼう) The downfall of a civilization or the dying-out of a certain ethnic group.
(ほうかい) To collapse – said of a building, but also (figuratively) like ‘The collapse of communism.’
(はかい) Destruction. This usually means physical destruction, but if you’re looking for a word with the ‘this will be your downfall!’ blame-a-dude aspect, 破壊 works better than the previous two.
(ぜつめつ) (for animals) To go extinct.
Neither 滅亡 nor 崩壊 have the moral ‘It’s your own fault’ judgment of the English word ‘downfall.’